Abstract
Virology Although viral hepatitis is a major cause of morbidity worldwide, scientists lack good small-animal models for studying it, especially models that recapitulate virus-caused liver pathology. Hirai-Yuki et al. report a mouse model for infection with hepatitis A virus (HAV). HAV-infected mice lacked type I interferon signaling, causing many symptoms similar to those of acute HAV in humans, including low-grade viremia and cell death and inflammation in the liver. Liver pathology depended on the innate immune signaling protein MAVS and interferon response factors 3 and 7. The use of these mice may provide important insights into the causes of viral hepatitis–dependent pathology in humans. Science , this issue p. [1541][1] [1]: /lookup/doi/10.1126/science.aaf8325
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