Modeling Current Dipoles Generated by Dendritic Currents

Abstract

Event Abstract Back to Event Modeling Current Dipoles Generated by Dendritic Currents Seppo Ahlfors1* and Christopher Wreh1 1 Massachusetts General Hospital, United States Current dipole is a basic unit describing sources of MEG and EEG signals within small regions of the cerebral cortex. Relating the properties of the macroscopic current dipoles to the characteristic patterns of underlying microscopic currents could help to better interpret MEG and EEG data in terms information flow in the brain. We constructed a model pyramidal cell, in which the spatial distribution of inputs from excitatory and inhibitory synapses within the dendritic tree was systematically varied. Using the distribution of post-synaptic currents in the model neuron, the net current dipole moment was determined. Both the magnitude and the direction of the current dipole were found to depend on the location of the synaptic inputs within the apical dendrite. Biophysical computational modeling of the postsynaptic currents within cortical pyramidal cells provides a means to examine the relationship between the patterns of synaptic inputs and the macroscopic current dipoles detected by MEG and EEG. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MEG Modeling Citation: Ahlfors S and Wreh C (2010). Modeling Current Dipoles Generated by Dendritic Currents. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00085 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Mar 2010; Published Online: 23 Mar 2010. * Correspondence: Seppo Ahlfors, Massachusetts General Hospital, Charlestown, United States, seppo@nmr.mgh.harvard.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Seppo Ahlfors Christopher Wreh Google Seppo Ahlfors Christopher Wreh Google Scholar Seppo Ahlfors Christopher Wreh PubMed Seppo Ahlfors Christopher Wreh Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.