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Abstract
Cancer Therapy Pharmacological inhibitors of DNA repair pathways can enhance the efficacy of chemotherapy. Alkan et al. modeled cancer cell responses to various chemotherapies and tested the efficacy of combining chemotherapy with DNA repair inhibition. In addition to the expected synergy between chemotherapy and an inhibitor of ATR (a DNA repair pathway kinase) in cultured cells and in vivo, there were some unexpected differences in outcome when applying low-versus high-dose chemotherapy regimens. Thus, modeling in cells can help inform therapeutic development. Sci. Signal. 11 , eaat0229 (2018).
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