Abstract
Recent experimental findings have begun to unravel the implication of the cerebellum in high-level functions such as spatial cognition [1,2]. We focus on behavioral genetic data showing that L7-PKCI mice (lacking LTD at parallel fibers-Purkinje cell synapses) have a spatial learning impairment in the Morris Watermaze (MWM), whereas they exhibit normal performances in the Starmaze, a paradigm that reduces the procedural demand of the task [3]. These results suggest that cerebellar learning may prominently contribute to the procedural component of spatial learning [3].
Highlights
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf
We focus on behavioral genetic data showing that L7-PKCI mice have a spatial learning impairment in the Morris Watermaze (MWM), whereas they exhibit normal performances in the Starmaze, a paradigm that reduces the procedural demand of the task [3]
These results suggest that cerebellar learning may prominently contribute to the procedural component of spatial learning [3]
Summary
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf . Modeling cerebellar learning for spatial cognition Jean-Baptiste Passot*1,2, Laure Rondi-Reig1,2 and Angelo Arleo1,2 Open Access from Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Berlin, Germany.
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