Abstract

Using a group of well annotated non-small cell lung cancer (NSCLC) cell lines (mutation status, gene expression profiling, siRNA profiling) selective and non-selective cytotoxic natural products can be identified based upon data of the sensitive cell lines. We have focused our efforts on discovery of natural products from marine-derived bacteria through the screening of a collection of ˜6500 natural product fractions. A screen of the 6500 natural product fractions against 27 non-small cell lung cancer cell lines has revealed a number of promising fractions.

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