Abstract
The cerebral cortical surface of the mature human brain is folded, and the pattern of gyri (ridges of the folds) and sulci (valleys of the folds) relates to behavioral attributes, such as the risk for neuropsychiatric disease. Axons, which populate white matter tissue adjacent to the cortex and mediate long-range neural connections in the brain, are known to grow in response to applied mechanical force. This connection between macroscopic forces and cellular development indicates that brain morphogenesis relates to its function at maturity.
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