Abstract
The general triaxial ellipsoid model for the gross conformation of macromolecules in solution represents a signficiant advance over the previously, almost ubiquitously used ellipsoid of revolution model. A new method is presented which involves the graphical intersection of two triaxial hydrodynamic functions (Λ and R) involving viscosity, sedimentation and fluorescence depolarization. The method is restricted to macromolecules asymmetric enough for the functions to be sufficiently sensitive but not so asymmetric for there to be problems of internal rotations between parts of the macromolecules. The method is illustrated by application to data for neurophysin II monomers and dimers.
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