Abstract
BackgroundThe activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes.MethodsIn this work, a kinetic model structure is developed to describe the major activation and inactivation processes in vertebrate rod photoreceptors with the electroretinogram (ERG) as output. Simulation was performed to validate developed model structure.ResultsThe developed model structure could fit experimental data with small error.ConclusionsThe result indicated that the developed model structure could show the inactivation process of phototransduction cascades in the rod photoreceptors.
Highlights
The activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes
The electrical current or voltage from the photoreceptors is an important part of electroretinogram (ERG), which is the summation of a few components of extracellular currents from different cells [13, 25, 28]
Estimation of reaction rates from measured ERG signal can be very useful for diagnosis; it is meaningful to develop a kinetic model structure with reaction rates as parameters for both the activation and inactivation processes
Summary
The activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes. Methods: In this work, a kinetic model structure is developed to describe the major activation and inactivation processes in vertebrate rod photoreceptors with the electroretinogram (ERG) as output. Conclusions: The result indicated that the developed model structure could show the inactivation process of phototransduction cascades in the rod photoreceptors. Phenomenological analytical functions or stochastic events are often used to simulate the processes These efforts have significantly contributed to the understanding of phototransduction cascade and vision system. Estimation of reaction rates from measured ERG signal can be very useful for diagnosis; it is meaningful to develop a kinetic model structure with reaction rates as parameters for both the activation and inactivation processes. There is a lack of a mature kinetic model structure covering both the
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