Abstract
This paper presents a mathematical model for pH gradient ITP in a microfluidic system. The mathematical model is based on mass conservation, charge conservation and electroneutrality condition in the system. A finite volume based numerical model is developed to simulate pH dependent isotachophoresis (ITP) in microfluidic devices. Numerical results of pH dependent ITP are obtained for straight and dog-leg microchannels. For both channels, five ionic components are used to simulate the model ITP system. The ITP results obtained from dog-leg microchannel capture the band broadening and band dispersion observed in T-channel junction. However, no such dispersion is noticed for ITP in the straight microchannel.
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