Abstract
In the present work the artificial neural network linked genetic algorithm was applied for the optimization of fermentation media components like carbon and nitrogen sources for L-asparaginase production by Enterobacter aerogenes MTCC 2823 in submerged fermentation. Artificial neural network (ANN) based back propagation algorithm was used to train and test the neural network using the experimental activity obtained by central composite design. Higher value of coefficient of determination (R2=0.984) of artificial neural network justified an excellent correlation between the media components and L-asparaginase activity, the artificial neural network model fitted well with high statistical reliability and significance than RSM model (R2=0.871) developed by central composite design. The predicted optimum concentration of the media components using artificial neural network linked genetic algorithm was sodium citrate 2.09%, DAHP 0.25% and L-asparagine 0.92% with the maximum predicted L-asparaginase activity of 18.59 IU/mL which was close to the experimental L-asparaginase activity of 18.72 IU/mL at simulated optimum conditions.
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