Modeling and design of magnetic sugar particles manipulation system for fabrication of vascular scaffold

Abstract

This paper reports a magnetic steering method for controlled porogen fabrication of scaffold for blood vessel regeneration. The method described involves generating gradient magnetic field by a combination structure of Helmholtz coils and Maxwell coils to propel particularly prepared magnetic sugar particles (MSPs) moving in fluid environment at desired trajectory and forming a specified 3D shape as templates for particulate leaching. The movement properties of MSP are theoretically analyzed and the corresponding dynamic mechanics model is established. Further the magnetic field distributions inside the combined coils are calculated and optimal control parameters of coils configuration are obtained. Preliminary motion control experiment is also conducted to prove the feasibility of proposed method. The result demonstrates that MSP cluster can be manipulated with average speed of 0.25 mm/s for a cluster of 12 MSPs and 0.116 mm/s for a cluster of 37 MSPs with the proposed coil system and used for improving interconnection of MSP dot patterns.