Model systems and clinical applications of hepatic stem cells for liver regeneration.

Abstract

Hepatic stem cells are capable to self-renew and to differentiate into all types of cells in the liver, including hepatic progenitors, mature hepatocytes and cholangiocytes. This review summarizes the recent advances in animal studies and the results of clinical trials over the last few decades. Studies in numerous animal models of liver diseases have demonstrated the efficacy of hepatic stem cells. Clinical studies of hepatic stem cells are also promising for a variety of hepatic diseases. With the accumulation of innovative and creative works, hepatic stem cells therapy will be a new approach for liver diseases.