Model Supports Use of Fractional Dosing of Yellow Fever Vaccine

Abstract

The yellow fever outbreak in Angola in 2015–2016 led WHO to recommend a dose-sparing strategy to protect more people in the face of insufficient yellow fever vaccine to cover all. For the population of Kinshasa of 12.5 million, who were also at risk, only about 2.5 million standard-dose vaccines were expected to be available. To assess whether a fractional-dosing strategy is likely to be effective, investigators have now used mathematical models …