Abstract
AbstractThe bimolecular rate constants for reaction of the enantiomers of isopropyl methylphosphonofluoridate, isopropyl p‐nitrophenyl methylphosphonate and isopropyl S‐2‐dimethylaminoethyl methylphosphonothioate with α‐cyclodextrin have been calculated from the dissociation constants (Kdiss) of the prereaction 1:1 inclusion complexes and the maximal rate constants (k2max) for the ensuing nucleophilic reactions. These data are compared with the corresponding rate constants for the inhibition of acetylcholinesterase.It is concluded that the stereospecificity exhibited by α‐cyclodextrin in its reaction with enantiomeric organophosphorus compounds is reflected mainly in the nucleophilic reaction.
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