Abstract
Computer modeling of 3D structure of full-length AIMP1/р43 - component of aminoacyl tRNA synthetase complex in higher eukaryotes, was performed. The model of the spatial structure of the dimer AIMP1/р43 was obtained. Experimental data on the content of the secondary structure of AIMP1/р43 was determined by circular dichroism method. The spatial structure of AIMP1/р43 allows to carry out structural and functional analysis of the interaction with other biologically important molecules
Highlights
IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content [Text] / Z
Comparative protein structure modeling with MODELLER [Text] / N
Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-step Atomic-level Energy Minimization [Text] / D
Summary
– вимірювання та аналіз КД-спектрів білка AIMP1/p43 у розчині; – побудова моделі просторової структури димеру АІМР1/р43. Передбачення вторинної структури та неструктурованих ділянок AIMP1/p43, виходячи з його амінокислотної послідовності, здійснювали з використанням веб-серверів: PrDOS (Protein DisOrder prediction System) [8] та IUPred (Prediction of Intrinsically Unstructured Proteins) [9]. Моделювання тривимірної структури білка АІМР1/р43 було виконано за допомогою програмного пакету Modeller 9.14 [12, 13].
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