Abstract
In this paper, we present a multi-source nanonetwork model for biomedical diagnosis applications, based on the Localized Surface Plasmon Resonance by different shape gold nanoparticles (i.e., cylinder, cube, and rod). We present the process of multi-source emission, diffusion, and reception of nanoparticles, based on the ligand/receptor binding. Then, a multi-detection process of DNA alterations is accomplished when nanoparticles are captured at the receiver. The colloidal particles are selectively functionalized with specific splice junctions of gene sequences to reveal simultaneously different alteration that could be associated to an early disease condition. Particularly, full-wave simulations have been carried out for the multi-detection of alternative splice junctions of breast cancer susceptibility gene 1. The proposed application is verified through numerical results and expressed in terms of Extinction-Cross Section, in the case of synchronous and asynchronous nanoparticles detection. We show that the proposed approach is able to detect DNA alterations, based on a selective nanoparticle reception process.
Highlights
In the past few decades, nanotechnology has emerged as a novel evolution of technology enabling the design of miniaturized devices at nanoscale level
In [2] the authors use a Quantum Dots-DNA (QDs-DNA) nanosensor based on Fluorescence Resonance Energy Transfer (FRET) for the detection of the target DNA and single mismatch in Hepatitis B Virus (HBV) gene
The electromagnetic response obtained from each nanoparticle must be different and independent in terms of resonant wavelength, amplitude and magnitude width, respectively
Summary
In the past few decades, nanotechnology has emerged as a novel evolution of technology enabling the design of miniaturized devices at nanoscale level (i.e., nanorobots and nanoparticles). At this scale, the behaviors and characteristics of nanodevices need more comprehension and a deep knowledge with respect to well-known features of devices at the macroscale level [1]. In [2] the authors use a Quantum Dots-DNA (QDs-DNA) nanosensor based on Fluorescence Resonance Energy Transfer (FRET) for the detection of the target DNA and single mismatch in Hepatitis B Virus (HBV) gene
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