Abstract
1208 The purpose of this investigation was to model isolated aortic cardiac baroreflex function (ABR) in humans. Pharmacologically-induced increases(phenylephrine) and decreases (nitroprusside) in aortic distending pressure were implemented in five healthy young normotensive subjects in order to determine the maximal gain (Gmax) of the reflex heart rate (HR) response in i) an intact ABR and carotid baroreflex (CBR) and ii) an isolated ABR. Mean arterial blood pressure (MAP) was monitored by an intra-radial arterial catheter. The threshold (THR), saturation point (SAT), response range(RES), centering point (CP) and minimum HR response (HRmin) were calculated using the Kent Logistical Model. The ABR was functionally isolated from the CBR by application of neck pressure during the hypertensive response and neck suction during the hypotensive response. Mean ± SE calculations presented in table below:TableThe Gmax of the ABR was 56% and the response range of the ABR was 81% of the arterial baroreflex (ABR+CBR). We conclude the ABR is the predominant reflex regulator of MAP.
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