Model for the Study of Drug Hypersensitivity Based on Bucilamine and the HLA-DRB1*08:02 Allele in Colombian Amerindian Populations

Abstract

Backgrounds: Allergic diseases and hypersensitivity reactions are common disorders that in turn consist of an extensive genetic component in which the molecules of the Major Histocompatibility Complex (MHC) are included, which have certain alleles associated with the development of hypersensitivity to certain drugs, among which is the allele HLA-DRB1 * 08: 02 as a predisposing factor of hypersensitivity to Bucillamine; this drug is the starting point for the study of the relationship between hypersensitivity reactions to medications and the expression of certain alleles of MHC. Objective: Find the relationship between hypersensitivity to the drug and the expression of the specific allele in Amerindian populations of the Sierra Nevada de Santa Marta and in turn suggest the application of the methodological model proposed in similar studies that seek to relate drug allergies with specific HLA alleles. Methods: A systematic search of information was carried out in the Sience, ScienceDirect, Elsevier and Pubmed databases, the frequencies obtained were tabulated and organized according to their expression to be analyzed with the MEGA7 software. Results: A significant frequency of the HLA-DRB1 * 08: 02 allele was found in the Ijka (61.7%), Arhuaco (41.5%), Kogi (17.9%) and Arsario (15%). Conclusion: A cautious use of Bucillamine and structurally similar drugs it’s recommended in susceptible Amerindian populations, at the same time the application of the proposed model it’s recommended for the study of different drugs that could trigger an allergic reaction based on HLA’s allele expression.