Model-based predictions of soil and dust ingestion rates for U.S. adults using the stochastic human exposure and dose simulation soil and dust model

Abstract

BackgroundAdults can be exposed to chemicals through incidental ingestion of soil and dust, either through hobbies, occupations, or behaviors that increase contact with soil or dust (e.g., cleaning or renovating). However, few data describing these ingestion rates are available. ObjectiveOur objective was to use the Stochastic Human Exposure and Dose Simulation Soil and Dust (SHEDS-Soil/Dust) model to estimate distributions of soil and dust ingestion rates for adults (≥21 years old) with varying degrees of soil and dust contact. MethodsWe parameterized SHEDS-Soil/Dust to estimate soil and dust ingestion rates for several categories of adults: adults in the general population; adults with moderate (higher) soil exposure (represented by hobbyists, such as gardeners, with increased soil contact); adults with high soil exposure (represented by occupationally exposed individuals, such as landscapers); and individuals who have high dust exposure (e.g., are in contact with very dusty indoor environments). ResultsTotal soil plus dust ingestion for adults in the general population was 7 mg/day. Hobbyists or adults with moderate soil exposure averaged 33 mg/day and occupationally exposed individuals averaged 123 mg/day. Total soil plus dust ingestion for adults in the high dust exposure scenario was 25 mg/day. Results were driven by time spent in contact with soil and, thus, warmer seasons (e.g., summer) were associated with higher ingestion rates than colder seasons (e.g., winter). SignificanceThese results provide modeled estimates of soil and dust ingestion rates for adults for use in decision making using real-world exposure considerations. These modeled estimates suggest that soil and dust ingestion is a potential concern for adults who spend a higher amount of time interacting with either soil or dusty environments. Impact statementThe parameterization of real-world scenarios within the application of SHEDS-Soil/Dust model to predict soil and dust ingestion rates for adults provides estimates of soil and dust ingestion rates useful for refining population-based risk assessments. These data illuminate drivers of exposure useful for both risk management decisions and designing future studies to improve existing tracer methodologies.