Abstract
This contribution presents an integrated approach to the optimal operation and automatic control of chromatographic separation processes in batch elution mode as well as in continuous SMB operation. The new approach is based on computationally efficient simulation models and combines techniques from mathematical optimization, parameter estimation and control theory. The resulting algorithms were implemented in an industrial standard control system and the capability of the proposed control approach is demonstrated on the separation of fructose and glucose, both in batch and SMB operation mode.
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