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Abstract
1. 1. FK336 f(10 −6–10 -4M) inhibited contractile responses to norepinephrine (NE), KCl and Ca 2+ in isolated rabbit aortas. 2. 2. Relaxing effect of FK336 on KCl-response was inhibited by nitroglycerin (NG), but not by nifedipine or verapamil. 3. 3. FK336 inhibited residual NE response and a subsequent Ca 2+ response in Ca 2+-free medium. FK336 did not affect the inositol monophosphate level. 4. 4. Relaxing effect of FK336 on NE response was inhibited by methylene blue, NG, K +-channel inhibitors and acetylcholine (ACh), and potentiated by M&B 22,948 and theophylline. 8-Br cGMP and dibutyl cAMP had no effect. 5. 5. FK336 increased cGMP level in rat aorta. 6. 6. Potentiation of isoproterenol-relaxation by FK336 was inhibited by methylene blue. 7. 7. The inhibitory effect of ACh on FK336-relaxation was eliminated by endothelium removal, nordihydroquaiaretic acid and guinacrine, but not by indomethacin. These treatments themselves did not affect FK336-relaxation. 8. 8. The mode of vasorelaxing action of FK336 is discussed.
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