Abstract
The International Scientific Research Organization for Science, Engineering and Technology (ISROSET) is a Non-Profit Organization; The ISROSET is dedicated to improvement in academic sectors of Science (Chemistry, Bio-chemistry, Zoology, Botany, Biotechnology, Pharmaceutical Science, Bioscience, Bioinformatics, Biometrics, Biostatistics, Microbiology, Environmental Management, Medical Science, Forensic Science, Home Science, Library Science, Material Science Military Science, Physical Science, Physical Education Science, Educational Science, Fisheries, seed technology, Agriculture, Forestry Science, Mathematics, Physics, Statistics and Geology/Earth Science), Computer Science, Engineering and Information Technology, Commerce, Management, Economics Sociology and Social Science.
Highlights
Brain tumor (GBM-Glioblastoma) is one of most serious malignant tumor of central nervous system [1,2] and characterised by their aggressiveness, angiogenesis, deregulation of apoptosis, proliferation and difficult to treat with conventional therapies such as surgery, radiotherapy and chemotherapy
We found that flavonoids induced p38 and Nf-kβ gene expression significantly reduced and these observations showed that p38 and Nf-kβ gene expression suppressed with flavonoids and regulate
We observed the role of flavonoids in regulation of brain tumor invasion
Summary
Brain tumor (GBM-Glioblastoma) is one of most serious malignant tumor of central nervous system [1,2] and characterised by their aggressiveness, angiogenesis, deregulation of apoptosis, proliferation and difficult to treat with conventional therapies such as surgery, radiotherapy and chemotherapy. It’s too difficult to treat GBM and need to develop a novel therapy for prevent and treat Glioblastoma. Aloe plant used as medicine in rural area and its flavonoids is used as drug for prevention of tumors because it can suppress brain tumor cells growth and progression and improved patient health from this lethal malignancy. Aloe-emodin, aloesin, barbaloin, acemannan and anthreaquinone are major polyphenolic flavonoids, have been shown to inhibit the growth of brain, breast, ovary, lung and leukaemia cancer [11,12,13]
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