Abstract
1. 1. The activity of the overall Na +-K +-ATPase reaction was inhibited by indomethacin in vitro. 2. 2. The K +-NPPase activity was also inhibited by indomethacin. 3. 3. The activity of Na +-dependent phosphorylation of Na +-K +-ATPase was activated by indomethacin. 4. 4. Indomethacin required for 50% inhibition of K +-NPPase activity was 0.4 mM. 5. 5. Inhibition mode of indomethacin for both the substrate and K + in K +-NPPase reaction was competitive type. 6. 6. The K i values for indomethacin for the substrate and K + in K +-NPPase reaction were 0.4 and 0.24 mM, respectively. 7. 7. Inhibitory effect of indomethacin on K +-NPPase was reversible.
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