Abstract
The effect of phenformin plus ethyl-œstrenol on fibrinolysis, using the dilute-blood-clot and euglobulin-lysis-time methods together with the areas lysed on human fibrin plates by the euglobulin fraction of plasma during treatment, was studied in 6 patients with occlusive vascular disease. The results show that the drugs increase the level of plasminogen activator in blood and thus have a truly fibrinolytic effect; they do not support the suggestion put forward by others that they are not fibrinolytic drugs but act by rendering fibrin more susceptible to lysis.
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