Abstract
Chemical and biological investigation of the cultured marine soft coral Xenia elongata led to the isolation of two new diterpenes (2, 3). Their structures were elucidated using a combination of NMR and mass spectrometry. Biological evaluations and assessments were determined using the specific apoptosis induction assay based on genetically engineered mammalian cell line D3 deficient in Bak and Bax and derived from a mouse epithelial cell. The diterpenes induce apoptosis in low micromolar concentrations. The results indicate that the previously isolated compound (1) affects cell in a manner similar to that of HSP90 and HDAC inhibitors and in a manner opposite of PI3 kinase/mTOR inhibitors. Compound (3) inhibits selectively HDAC6 in high micromolar concentrations.
Highlights
Natural products are the most reliable and rich source of new anticancer entities
In our ongoing effort to discover and develop new marine natural product biomedicinals, and in order to explore the diversity of natural products from the soft coral Xenia elongata, chemical and biological investigation of this organism were undertaken
Live colonies of Xenia elongata were grown in the coral laboratory at the Marine Biotechnology
Summary
Natural products are the most reliable and rich source of new anticancer entities. Over the past years, nearly 63% of anticancer drugs introduced to the pharmaceutical development market are. The soft coral of the genus Xenia elongata has produced interesting biological molecules, apoptosis inducer compounds [3,4]. These molecules embed a framework of nine-membered rings and a particular arrangement of functional groups with multiple stereocenters. These structural features limit the range of chemical reactions that are applicable to their synthesis. In our ongoing effort to discover and develop new marine natural product biomedicinals, and in order to explore the diversity of natural products from the soft coral Xenia elongata, chemical and biological investigation of this organism were undertaken. HDAC inhibitory assay of 3 was displayed and discussed
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