Mode and site of action of clomiphene

Abstract

Direct action of clomiphene citrate upon the hypothalamus, especially on the median eminence and the anterior hypothalamus was demonstrated by the increase of plasma and pituitary LH following the stereotaxic implantation of clomiphene into the rat brain. Subcutaneous 5 day injection of clomiphene also increased both LH release and synthesis in rats. FSH release from the pituitary increased transiently, but FSH synthesis was not simulated following both the subcutaneous injection and the intra-hypothalamic implantation of clomiphene. These results indicate the mode and site of action of clomiphene citrate in the induction of human ovulation.