Abstract
We investigated modality differences in the N2 and P3 components of event-related potentials (ERPs) between somatosensory and auditory Go/No-go paradigms in eighteen healthy prepubescent children (mean age: 125.9±4.2 months). We also evaluated the relationship between behavioral responses (reaction time, reaction time variability, and omission and commission error rates) and amplitudes and latencies of N2 and P3 during somatosensory and auditory Go/No-go paradigms. The peak latency of No-go-N2 was significantly shorter than that of Go-N2 during somatosensory paradigms, but not during auditory paradigms. The peak amplitude of P3 was significantly larger during somatosensory than auditory paradigms, and the peak latency of P3 was significantly shorter during somatosensory than auditory paradigms. Correlations between behavioral responses and the P3 component were not found during somatosensory paradigms. On the other hand, in auditory paradigms, correlations were detected between the reaction time and peak amplitude of No-go-P3, and between the reaction time variability and peak latency of No-go-P3. A correlation was noted between commission error and the peak latency of No-go-N2 during somatosensory paradigms. Compared with previous adult studies using both somatosensory and auditory Go/No-go paradigms, the relationships between behavioral responses and ERP components would be weak in prepubescent children. Our data provide findings to advance understanding of the neural development of motor execution and inhibition processing, that is dependent on or independent of the stimulus modality.
Highlights
Event-related potentials (ERPs) obtained by time-locked averaging electroencephalography (EEG) with high temporal resolution have been used to investigate the neural substrates of motor execution and inhibition during Go/No-go paradigms for over 30 years
The present study did not directly address the differences in generator mechanisms of frontal N2 between somatosensory and auditory paradigms, but our findings suggest that the appearance itself of frontal N2 among children does not depend on sensory modalities, and the strength and speed of neural activities involve modality differences
The frontal N2 component was recorded among prepubescent children using visual and auditory Go/No-go paradigms [7,8,9,10,11,12,13], and our data showed that this component was detected even with a somatosensory Go/No-go paradigm
Summary
Event-related potentials (ERPs) obtained by time-locked averaging electroencephalography (EEG) with high temporal resolution have been used to investigate the neural substrates of motor execution and inhibition during Go/No-go paradigms for over 30 years. A higher commission error rate group would be related to lower amplitudes of visual Go-P3 and No-go-P3, compared with a lower group, even though RTs do not differ between the two groups [32] These data suggest that motor execution and inhibition in Go/No-go paradigms involves are closely related. By applying these findings, we hypothesized that the correlations between RT and the amplitudes of No-go-N2 and/or Nogo-P3, and/or between error rates and the amplitudes of Go-P3 and/or No-go-P3 were observed in prepubescent children during both somatosensory and auditory Go/No-go paradigms. These data would advance understanding of the neural development of motor execution and inhibition processing, which is dependent on or independent of the stimulus modality
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