Abstract
On the basis of both their modal DNA values and chromosome numbers (23 tumors), or their modal DNA values alone (38 tumors), 61 ovarian carcinomas fell into 2 discrete groups. Tumors in the low-ploidy (near-diploid) group had less often spread beyond the ovary or ovaries and showed a significantly better prognosis as compared with those in the high-ploidy (near-triploid-tetraploid) group. The low-ploidy tumors were on the average only slightly more differentiated than the high-ploidy tumors. More than one sample was obtained from 18 of the tumors; in 2 there were differences in different areas which possibly represented regional polyploidization of a single cell-line. The DNA modes of 14 benign ovaries were near-diploid, excepting a mucinous cystadenoma which was near-triploid and a serous cystadenoma which was near-diploid in some regions and near-tetraploid in others.
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