Abstract

PURPOSE: Obstructive sleep apnea (OSA), a common cause of excessive sleepiness, is associated with impaired mood and other negative outcomes. Nasal continuous positive airway pressure (nCPAP), a standard treatment for OSA, effectively improves airway patency, functional status, and excessive sleepiness. However, some patients experience residual excessive sleepiness even with regular nCPAP use. The novel wake-promoting agent modafinil is indicated for excessive sleepiness associated with narcolepsy, shift work sleep disorder, and residual excessive sleepiness in OSA as an adjunct to nCPAP. We report two double-blind studies of adjunct modafinil for residual excessive sleepiness in OSA patients using nCPAP.

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