MOD000001, a Novel Highly Selective and Orally Available KIT Inhibitor, Suppresses Passive Cutaneous Anaphylactic (PCA) Reaction and Food Allergy in Mice

Abstract

Mast cells (MCs) play a central role in the development of IgE-mediated allergic diseases, including allergic urticaria and food allergy. SCF/KIT signaling is essential for the differentiation, proliferation, survival, and activation of MCs. Thus, highly selective KIT inhibitors would have therapeutic potential for IgE/mast cell-mediated allergic diseases through homeostatic regulation of mast cells while minimizing side effects caused by the inhibition of non-KIT kinases, such as PDGFR and VEGFR.