Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study.

Chun-Hua Wang,Li-Fei Chen,Han-Pin Kuo,Te-Fang Sheng,Fu-Tsai Chung,Wen-Ching Joa,Pai-Chien Chou,Horng-Chyuan Lin,Kian Fan Chung,Shu-Chuan Ho,Chien-Da Huang

doi:10.1186/1471-2466-14-142

Chun-Hua Wang, Li-Fei Chen + Show 9 more

Open Access

https://doi.org/10.1186/1471-2466-14-142

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Abstract

BackgroundModerate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients.MethodsTo investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines.ResultsPatients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-α were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group.ConclusionsA mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019)

Highlights

Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in Chronic obstructive pulmonary disease (COPD) patients
We further explored whether the circulating levels of inflammatory markers, such as C-reactive protein (CRP), IL-6, tumor necrosis factor (TNF)-α, and IL-8 will be reduced in patients with COPD undergoing a mobile-phone assisted home-based exercise training program [23]
We demonstrated that COPD patients, under the assistance of a mobile phone, were able to perform a homebased, individualized endurance exercise training program at an intended walking speed controlled by a pre-set tempo of music

Summary

Introduction

Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients. Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction with chronic airway inflammation and emphysematous changes in the lung parenchyma [1,2]. COPD is characterized by persistent chronic inflammation that may extend beyond the pulmonary system, resulting in a state of Several systemic inflammatory markers or cytokines including C-reactive protein (CRP), IL-6, IL-8, and tumor necrosis factor (TNF)-α have been associated with COPD risk, COPD mortality, COPD exacerbations, or lung function decline [6,7,8,9]. IL-8 and TNF-α may be important signaling molecules for neutrophil activation

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