Abstract
The effects of mobile phase components on peak tailing and selectivity are examined for polar multi-functional solutes in liquid—solid chromatography on a silica gel adsorbent using various deoxynucleoside derivatives as sample solutes. Methanol is effective for suppressing peak tailing when combined with n-hexane as a diluent, but causes a decrease in the separation factor for pairs of deoxynucleoside derivatives. A combination of solvents is suggested for the diluent that will give an appropriate modification in separation factor so as to achieve maximum resolution of mixtures of polar multi-functional compounds.
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