Abstract

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Highlights

  • Terence Dwyer1,2, Gabriella Tikellis3, Akram Ghantous2, Stanley Lemeshow4, Siri E

  • Apart from a small fraction of CC cases that can be explained by ionizing radiation [5], compelling evidence linking environmental exposures or biological mechanisms and associated biological mechanisms to the broader occurrence of CC is lacking

  • We had become aware of a sixth cohort, the Chinese Children and Families Cohort Study (CFCS) of 242,000 subjects [11], but it was not clear at that time whether subjects in this cohort could be followed for CC

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Summary

CHILDHOOD CANCER

The overall incidence of childhood cancer (CC) is approximately 1 per million children per year and has been steady or increasing in most developed countries in recent decades [1,2,3]. Two additional more modest sized birth cohorts, the Tasmanian Infant Health Survey (TIHS) [9] and the Avon Longitudinal Study of Parents And Children (ALSPAC) [10], were known to the group and were included Each of these five studies had early life exposure measurements that were considered relevant to the study of CC, and all were able to follow subjects for cancer. We had become aware of a sixth cohort, the Chinese Children and Families Cohort Study (CFCS) of 242,000 subjects [11], but it was not clear at that time whether subjects in this cohort could be followed for CC While it became a member of I4C it is not yet providing data to the consortium. MoBa is one of five among the six more established I4C cohorts mentioned previously that are currently in a position to contribute to the pooled efforts of the I4C with both questionnaire data and biospecimens

Questionnaire data
Harmonization and pooling of data
RESEARCH EFFORTS
Findings
Availability and use of biospecimens
Full Text
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