MO865: Epidemiological Characteristics of Cancer in Incident Dialysis Patients. A Multicentre Spanish Study

Abstract

Abstract BACKGROUND AND AIMS There is evidence that cancer risk is increased in people with chronic kidney disease (CKD), specially when glomerular filtration rate decreases [1,2]. This association do appear to be site-specific [3,4]. Cancer incidence increases by time since first dialysis in addition [5]. The aim of our study is to describe characteristics of dialysis incident patients with diagnosis of malignancy in a multicentre spanish cohort. METHOD We performed a multicentre collaborative retrospective study over the period 2015–20 of clinical and demographical data from incident dialysis patients with diagnosis of cancer. Data from Seville, Cadiz, Marbella and Huelva was collected from the Registry of Renal Patients of the Andalusian Health Service (SICATA). Data from Canary Islands was collected from Registry of Renal Patients of the Canary Islands Health Service. Data from Cantabria was collected from the Registry of Renal Patients of Cantabrian Health Service. Rest of centres provided their own collected data (Gregorio Maranon General University Hospital and University Hospital October 12). Statistics: Quantitative variables are expressed as mean/-SD (normal distribution) or median (IQ 25–75) (non-normal distribution). Qualitative variables are expressed as percentage. RESULTS 727 incident dialysis patients were diagnosed with cancer before (79.9%) or after (20%) starting dialysis over the study period. Prevalence was 15.9% among all incident patients. 73.2% of patients were men with a mean age 70.1 (SD 10.3) years old. At the time of starting dialysis, 30.6% were smokers, 45.5% patients presented diabetes, 88% high blood pressure, 18.5% received immunosupresive therapy in the past, 4.1% had history of hepatitis B, C or HIV infection and mean proteinuria was measured in 2990 mg/g (SD 3832). Diabetic kidney disease and chronic tubulointerstitial nephritis were the most common causes of CKD (22.1% and 22.9%, respectively). 14.4% of patients had history of glomerular nephropathy. Mean time from CKD diagnosis to dialysis start was 6 years and from CKD diagnosis to cancer diagnosis was 5.4 years (SD 6.4). Solid cancer was found in 88% of patients and 12% had hematological malignancy. Most common malignancies were urinary tract cancers (bladder, 17%, kidney 17.3% and prostate 13.2%) followed by colon cancer, 11.27% of cases. 32% of patients had active neoplasia at the time of starting dialysis and 15.1% had metastatic disease. 33.8% of patients died over follow-up. Neoplastic disease was the most common cause of death (29.6%) followed by cardiovascular (19.5%) and infectious disease (16.2%). A total of 7.1% of patients underwent kidney transplant (previous malignancies were prostate, kidney cancer and multiple myeloma in majority of these cases). CONCLUSION Among our spanish multicentre cohort of incident dialysis patients, the average duration between the diagnosis of CKD and cancer was 5.4 years. The most commonly observed cancer sites were urinary tract and kidney malignancies, as previously reported in other cohorts. Study findings may be a useful reference for cancer screening guidelines in our population.