MO575SEX DISPARITY IN THE ASSOCIATION BETWEEN DIETARY SODIUM INTAKE AND THE RISK OF INCIPIENT OSTEOPOROSIS

Abstract

Abstract Background and Aims Rationale & Objective: Dietary nutrition is closely related with bone health, but there is wide controversy on the association of dietary sodium intake with bone densitometry (BMD) and risk of incipient osteoporosis. Method Study Design: Community-based retrospective cohort study Measurement: We used Tanaka method for estimating 24-h urinary sodium excretion (e24hUNaETanaka) as candidate indicator of dietary sodium intake. Setting & Participants: Using long-term follow-up cohort data from the Korean Genome Epidemiology Study, we identified 4310 participants without osteoporosis and classified them into quartile according to their e24hUNaETanaka. Outcome: Participants were followed up for 12 years of less for a new diagnosis of osteoporosis. Analytical Approach: Multiple Cox-proportional hazard model was performed to estimate hazard ratio (HR) of osteoporosis and survival curve analysis was utilized to compare cumulative survivals. Results Decreased dietary sodium intake was deeply related with low BMD parameters. Multiple Cox-proportional hazard model, adjusted for various conventional risk factors of decreased BMD, demonstrated that e24hUNaETanaka had inverse association with the risk of osteoporosis (adjusted HR = 0.868, 95% CI = 0.768-0.981). Interestingly, our RCS analysis revealed that there was wide variation in the relation between dietary sodium intake and the risk of incipient osteoporosis according to sex and female hormone status: negative curvilinear relationship in male participants; positive linear relationship in premenopausal female participants; and negative linear relationship in postmenopausal female participants. Conclusion Our findings suggest that decreased sodium intake was a significant predictor of osteoporosis progression and there was some sex disparity in the relation dietary sodium intake and the risk of incipient osteoporosis.