MO568: The Relationship Between Oxidative Stress and Undernutrition in CKD Patients

Abstract

Abstract BACKGROUND AND AIMS Undernutrition is frequent in patients with chronic renal failure. It affects 35% of patients at the start of dialysis and represents one of the causes of morbidity and mortality. The objective of this work is to determine the relationship between oxidative stress and undernutrition in patients at different stages of chronic renal failure. METHOD A descriptive longitudinal study of 162 patients with chronic renal failure at different stages (2, 3, 4, 5 and 5D). We have studied the biological and anthropometric nutritional parameters in CKD patients at different stages as well as markers of oxidative stress, and we have studied their correlations with undernutrition in these patients. RESULTS The mean age of the patients is 56.5 ± 17 years with a sex ratio of 1.43. Regarding markers of oxidative stress, MDA, MPO and AOPP were studied. The means of which are respectively (6.1 ± 0.12 μmol/L, 59 0.89 ± 1.98 IU and 61.89 ± 1.4 μmol/L). The average body mass index, albumin and pre-albumin levels are respectively: (21.98 ± 0.28), (37.84 g/L ± 0.47) and (302.93 mg/L ± 5.4). All three parameters decrease significantly (P <0.05) with degradation of renal function (from stage 2 to stage 5D) and increase in markers of oxidative stress with a negative correlation (P < 0.05). The most undernourished patients are found in stage 5 and 5D with high levels of oxidative stress markers. Undernutrition is greater in patients with severe CKD and in hemodialysis patients with high levels of oxidative stress markers. CONCLUSION Chronic renal failure represents a real public health problem. Undernutrition is one of the causes of morbidity and mortality in these patients, especially after extra renal treatment, hemodialysis, oxidative stress worsens undernutrition and cardiovascular morbidity.