MO564: The Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Cardiovascular Disease in Patients with Chronic Kidney Disease

Abstract

Abstract BACKGROUND AND AIMS Recently, monocyte count to HDL-C ratio (MHR) has emerged as a new cardiovascular prognostic marker. However, few studies have evaluated the impact of this marker on cardiovascular endpoints in moderate-to-severe chronic kidney disease (CKD). Therefore, we aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR) is associated with cardiovascular diseases (CVD) in patients with CKD. METHOD In this retrospective study, carried out at nephrology department of Mohammed VI University hospital of Marrakesh, 110 patients with stage 3–5 CKD were recruited. MHR was calculated for all patients. The presence of heart failure, coronary artery disease or arrhythmia was defined as CVD. RESULTS Monocyte/HDL cholesterol ratio was negatively correlated with estimated glomerular filtration rate (eGFR) (P < 0.001). The study cohort was divided into tertiles based on MHR. Cardiovascular diseases were more common in patients in the highest tertile of MHR with a hazard ratio of 2.41 compared with the lowest tertile. The association remained significant after adjusting for established cardiovascular risk factors including age, gender, diabetes mellitus, hypertension, eGFR and smoking status. CONCLUSION The present study revealed that MHR is strongly associated with CVD in patients with pre-dialysis CKD. Therefore, this easily available inflammatory marker might be useful to predict CDV in patients with CKD, especially in low-income settings.