MO510OLFACTORY AND GUSTATORY DYSFUNCTION AMONG PATIENTS WITH KIDNEY IMPAIRMENT

Abstract

Abstract Background and Aims Poor appetite and food aversion are common in chronic kidney disease patients. Olfactory and gustatory function changes might be attributed to poor appetite among this population. Nevertheless, the associations between impaired kidney function and olfactory and gustatory dysfunction are less clear. Moreover, the prevalences of olfactory and gustatory dysfunction among patients with impaired kidney function have not been reported. Method We conducted a cross-sectional study among 3,529 US adults aged ≥ 40 years old in the National Health and Nutrition Examination Survey (NHANES) 2013-2014. We calculated the prevalences of olfactory and gustatory dysfunction among patients with impaired kidney function aged ≥ 40 years old by using analytic survey weights and design factors. We also examined the association between impaired kidney function and olfactory and gustatory dysfunction as well as the association between olfactory and gustatory dysfunction and nutritional markers among patients with impaired kidney function using weighted multivariable linear regression and logistic regression. Results The prevalences of olfactory impairment and gustatory dysfunction among impaired kidney function participants were 25% and 14%, respectively. After adjusting for confounders, impaired kidney function was significantly associated with higher odds of olfactory dysfunction (OR = 1.29, 95% CI [1.03, 1.60]; p=0.04) but not gustatory dysfunction (OR = 1.41, 95%CI [0.96, 2.09]; p=0.08). Among impaired kidney function population, olfactory dysfunction was significantly associated with lower serum albumin and grip strength but not serum total cholesterol, LDL-cholesterol or protein-energy malnutrition. However, gustatory dysfunction was not significantly associated with any nutritional markers among the impaired kidney function population. (Figure 1) Conclusion Impaired kidney function was associated with higher odds of olfactory but not gustatory dysfunction. Among those with impaired kidney function, only olfactory but not gustatory dysfunction was associated with lower serum albumin and grip strength.