MO508HEMATOCRIT, UREA AND GENDER (HUGE) EQUATION AND CARDIOVASCULAR EVENTS: A PROSPECTIVE STUDY IN SPANISH POPULATION

Abstract

Abstract Background and Aims To evaluate the relationship between chronic kidney disease (CKD) diagnosed by the hematocrit, urea and gender (HUGE) equation and the incidence of major adverse cardiovascular events and cardiovascular mortality in a sample of Spanish general population. Method The sample consisted of 2,668 subjects (mean age, 50.6±14.5 years; 54.6% were female). Of them, 55 patients have a HUGE score > 0. The median follow-up was 81 (75-89) months. Serum creatinine, urea and haematocrit were analyzed after overnight fast. The HUGE formula score was calculated for all subjects. Results Event-free survival was 98.4 % at three years and 97.1% at five years of follow-up for patients with a HUGE score < 0. For patients with a estimated HUGE score higher than 0 survival was 88.9% at three years and 87.0 at five years of follow-up. (p<0.0001). Cardiovascular death survival was 94.4 % at three and 88.0 at five years of follow-up for patients with a HUGE score higher than 0. For patients with a estimated HUGE. score lower than 0 survival was 99.3% at three years, and 99.0% at five years of follow-up. (p<0.001). Conclusion A significantly increased cardiovascular risk was associated to the diagnosis of CKD through HUGE formula. This effect on survival could be detected despite of a very small sample of CKD patients. This relationship was close to those obtained using MDRD estimated GFR in a bigger sample of patients. HUGE formula may be a useful tool for diagnosing CKD and to evaluate the cardiovascular risk of these patients.