MO489: Weight Change and Risk of Depression in Patients With Diabetic Kidney Disease: A Nationwide Population-Based Study

Abstract

Abstract BACKGROUND AND AIMS Several studies have reported that depression has a high prevalence in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD). METHOD From the Korean National Health Insurance Service database, we selected 67 866 patients with DKD with body weight data from two consecutive health examinations with a 2-year interval between 2009 and 2012. The weight change >2 years was categorized into five groups: ≥10% weight loss, 5%–10% weight loss, <5% weight change, 5%–10% weight gain and ≥10% weight gain. The occurrence of depression was monitored through the end of 2018 by the ICD-10 codes. RESULTS During the 5.24-year follow-up, 17 023 patients with DKD developed depression. The weight change and the risk of depression showed a U-shaped relationship: patients with ≥10% weight loss [hazard ratio (HR): 1.116] and those with ≥10% weight gain (HR: 1.114) showed higher HRs than those with ≤5% weight change, even after adjusting for several confounding factors. In subgroup analyses, the risk of depression tended to increase as weight gain or weight loss increased in all subgroups. CONCLUSION Both weight loss and weight gain increased the risk of depression in patients with DKD