MO27-2 Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer

Ari Nishimura,Yokota Tomoya,Hamauchi Satoshi,Onozawa Yusuke,Shirasu Hiromichi,Notsu Akifumi,Sato Fuyuki,Kawakami Takeshi,Ogawa Hirofumi,Onoe Tsuyoshi,Mukaigawa Takashi

doi:10.1016/j.annonc.2022.05.172

Ari Nishimura, Yokota Tomoya + Show 9 more

Open Access

https://doi.org/10.1016/j.annonc.2022.05.172

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Journal: Annals of Oncology	Publication Date: Jul 1, 2022
License type: publisher-specific-oa

Affiliation: Shizuoka Cancer Center

Abstract

Postoperative chemoradiotherapy is a standard therapy for the high risk patients with poor prognostic factors of the head and neck squamous cell carcinoma. Although incomplete resection and extra-nodal extension (ENE) were identified as postoperative prognostic factors in the combined analysis of the EORTC 22931 and the RTOG 9501 trials, other factors including the number of pathological metastatic lymph nodes (pLNs) were not significant. Furthermore, proportion of hypopharyngeal cancer (HPC) was small in those trials, and the prognostic impact of the number of pLNs in patients with HPC has been controversial.

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