Mo2095 Distinct Expression Levels of Voltage-Gated Sodium Channels in Guinea Pig and Mouse Prevertebral Ganglion Neurons Are Unchanged During Colitis

Abstract

patients. Results: A total of 197 patients (33 men and 164 women, ages 18 to 82 years) completed the Nausea Locator. The locations were classified into six groups by anatomic region where subjects felt their nausea: 1) upper abdomen (epigastrium) and substernal chest nausea (n=70, 35%); 2) upper abdomen (epigastrium) nausea (n=61, 31%); 3) periumbilical nausea (n=29, 15%); 4) substernal chest nausea (n=23, 12%); 5) lower abdomen nausea (n=8, 4%), and 6) neck area nausea (n=6, 3%). Conclusion: Only 31% of patients located their nausea in the epigastrium only. The most frequent location of nausea was the epigastrium and substernal chest region, suggesting stomach and esophagus origins of nausea. Surprisingly, almost 20% of the patients mapped their nausea to the periumbilical and lower abdomen regions, suggesting small bowel or colonic origins of nausea. The distinct topographies of nausea designated by the patients suggest the underlying pathophysiology of nausea may involve not only the esophagus and stomach but also the small bowel and colon.