Mo1940 Prevalence and Risk Factors of Colonic Adenomas Among 1133 40-49 Years Old Undergoing Screening Colonoscopy

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Growing evidence suggests that metabolic syndrome is not only a cluster of risk factors for cardiovascular disease and type 2 diabetes, but also for some cancer including a colorectal cancer. We have previously shown that insulin resistance, an increased visceral fat, hypoadiponectinemia and low-grade systemic inflammation assessed by serum IL-6 levels are linked to the risk of colorectal adenoma. Recently, it has been reported that chemerin, as a novel adipokine, can act as a chemoattractant for immune cells. And obesity, insulin resistance and inflammation have shown to have elevated serum levels of chemerin. However, the role of chemerin in human colorectal adenoma is still unknown. Therefore, we investigated the relationship between serum chemerin levels and the incidence of colorectal adenoma. Methods: We conducted a total colonoscopy-based cross-sectional case-control study. 76 male individuals with an endoscopically diagnosed colorectal adenoma were enrolled along with 72 age-matched male for our control group. Both cohort groups underwent health checkups, between 2007 and 2009, at Tohoku Central Hospital. Serum levels of chemerin were measured in samples of venous blood obtained from the participants after an overnight fast. The risk for colorectal adenoma was evaluated by logistic regression analysis. Results: In the colorectal adenoma group, the mean levels of serum insulin, fasting, plasma glucose, value of HOMA-IR and HbA1c were higher than those in the control group. There were no differences between the groups in the proportions of current smokers, alcohol consumers, mean BMI, bold pressure and serum triglyceride. The mean concentration of serum chemerin was significantly higher in the colorectal adenoma group than in the control group (791±354 ng/ml vs. 538±401 ng/ml, p<0.001). In multivariate analysis, high chemerin level (above the median) was associated with the incidence of colorectal adenoma (OR 2.9, 95%CI; 1.456.09) after adjustment for age, blood pressure, BMI, triglyceride, HOMA-IR and HbA1c. In conclusion, the present study suggests that increased serum levels of chemerin are positively associated with the incidence of colorectal adenoma in men. Our study indicates that chemerin may play an important role in the development of human colorectal adenoma. To confirm our findings in this study, further replication and research are required to elucidate the underlying the mechanisms. This will enable us to gain a better understanding of the link between metabolic syndrome and colorectal adenoma.