Mo1873 Menetrier's Disease Is Associated With an Increased Risk of Gastric Cancer: A Case-Control Study

Abstract

G A A b st ra ct s malignancies (1.3%). FD was diagnosed in the remaining 3,426 (75.4%) patients with a female preponderance (odds ratio [OR], 1.41; 95% CI 1.23-1.62). The prevalence of FD declined with age (84.9% at age,40 years; 76.3% at 40-49, 75.2% at 50-59, 70.8% at 6069 and 64.6% above 70 years, P,.001). Using Rome III criteria, 68.7% of these FD cases were classified as epigastric pain syndrome (EPS); 8.7% as postprandial distress syndrome (PDS); and 22.6% as overlap condition. There was no significant relationship between Helicobacter pylori infection and any type of FD (23.5%, 23.3% and 24.1%, respectively, P= .9). Other GI complaints were heartburn accounting for 2.4%, globus pharyngeus 11.1%, bloating 41.7%, diarrhea 7.3% and constipation 20.9%. Concomitant heartburn was more frequently occurred in subjects with EPS (OR, 1.31; 95% CI 1.04-1.65). Individuals with PDS were more likely to report coexisted bloating (OR, 4.24; 95% CI 3.25-5.52), diarrhea (OR, 1.66; 95% CI 1.13-2.44) and constipation (OR, 1.49; 95% CI 1.14-1.96). The frequency of irritable bowel syndrome (IBS) among FD patient was 8.3% (95% CI 7.4-9.3%). The overlap between FD and IBS was associated with female sex (OR, 1.38; 95% CI 1.05-1.82) and the presence of PDS (OR, 1.84; 95% CI 1.29-2.63). The use of proton pump inhibitors longer than 3 months tends to be associated with FD-IBS overlap but the difference did not reach statistical significance (OR, 1.28; 95% CI 0.99-1.64, P=.051). Conclusion: FD is the most common cause of dyspeptic symptoms in our patient population. Overlap of FD and reflux symptoms is commonly seen in individuals with EPS whereas FD-IBS overlap is often observed in those with PDS. The association between these conditions could provide valuable insights into pathophysiology of functional GI disorders.