Mo1837 Efficacy of Immunotherapy and Alergen-Molecular-Study-Led Diet Treatments in Eosinophilic Esophagitis

Abstract

BACKGROUNDA B=4.97; C=3.27; p=0.04), but no differences were observed between groups B and C (p=0,17). Regarding endoscopic findings, inflammatory features were significantly decreased after histological remission (furrows A=75%; B=72.7%; C=22.4%; p=0.003; exudates A=50%; B=48.5%; C=6.7%; p=0.01), but not fibrostenotic features ( rings A=71.4%; B=56.3%; C=53.3%; p=0.37; stricture A=10.7%; B=6.1%; C=6.7%; p=0.78). Mucosal edema was common at baseline and persistent regardless of histological remission (A=78.6%; B= 81.8%; C=66.7%; p=0.5). CONCLUSIONS: EoE clinical activity significantly decreased after different therapeutic interventions, with no differences between patients showing eosinophilia remission or persistence after therapy. Histological remission was correlated with significant decrease of inflammatory endoscopic features, but not of fibrostenotic findings. Mucosal edema was mostly persistent regardless of histological remission, suggesting it might belong to the fibrotic remodelling spectrum. Characteristics of the groups