Abstract
G A A b st ra ct s normal p<0.05, CAC v. colitis p=0.09, n=3). Western blot analysis demonstrated significant decrease in MCT 1 protein in CAC compared to normal but not colitis alone. On histological analysis, subtle changes were seen in colitis and CAC tissue when compared to normal. Conclusion: In the proximal colon of rats with CAC, activity of both NHE3 and MCT1 are inhibited significantly. However, MCT1 is inhibited secondary to a reduction in apical membrane transporters unlike NHE3 in CAC. Thus, these two apical membrane exchangers are uniquely regulated during CAC in the rat proximal colon. It is hypothesized that inhibition of MCT1 secondary to a reduction in exchanger numbers may result in increased pHi which could secondarily inhibit NHE3 without altering transporter numbers.
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