Abstract
active in CD Paneth cells. TEM high magnification observation revealed that autophagy activation was associated with a significant decrease in the number of secretory granules in CD patients. The granules appeared to be wrapped around autophagolysosomal vacuoles and abnormally degraded. Conclusion: This work describes of a novel selective autophagy pathway, called crinophagy that targets specifically secretory granules of CD Paneth cells. This process consists of the self-digestion of secretory granules by the autophago-lysosomal pathway. Crinophagy may explain the decrease of CD secretory granule observed in our study as well as the disorganization of the secretory granules and the exocytosis defect previously reported in CD.
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