MO172: Correlation of Serum Adipocyte Fatty Acid Binding Protein Level and Peripheral Arterial Disease in Chronic Kidney Patients

Abstract

Abstract BACKGROUND AND AIMS Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, dendritic cells and macrophages and it was thought to be involved in insulin resistance, chronic inflammation and atherosclerotic processes. Peripheral arterial disease (PAD) is associated with all-cause mortality, cardiovascular events and a key pathological process is atherosclerosis. The present study aimed to determine the relationship between serum A-FABP level and PAD in patients with non-dialysis chronic kidney disease (CKD). METHOD Fasting blood samples and baseline characteristics were obtained from 260 non-dialysis CKD patients (CKD stage 1–5). Ankle-brachial index (ABI) values were measured using an automated oscillometric device. Patients with ABIs of <0.9 were categorized into the low ABI group. Serum A-FABP levels were measured using a commercial enzyme immunoassay assay. RESULTS In the study cohort, 32 of the 260 non-dialysis CKD patients (12.3%) had low ABIs. The rates of diabetes mellitus (P = .037), smoking (P = .030), older age (P = .002) as well as the serum levels of A-FABP (P = .003) were higher in the low ABI group compared with the normal ABI group. The multivariable logistic regression analysis revealed that serum levels of A-FABP [odds ratio (OR): 1.223, 95% confidence interval (CI): 1.068–1.401, P = .004], older age (OR: 1.064, 95% CI: 1.026–1.104, P = .001) and smoking (OR: 4.438, 95% CI: 1.493–13.198, P = .007) were the independently associated with PAD in patients with CKD. By receiver operating characteristic (ROC) curve analysis, the area under the receiver operating characteristic curve of A-FABP level was 0.662 (95% CI: 0.601–0.719, P = .0004) for predicting PAD in non-dialysis CKD patients. CONCLUSION In this study, serum A-FABP levels were associated with PAD in patients with non-dialysis CKD.