Mo1678 Classification of Indeterminate Pancreaticobiliary Strictures Pre- and Post-Biliary Stenting by Probe-Based Confocal LASER Endomicroscopy

Abstract

transit time (MTT). The findings were compared with pathological/cytological results or long time of follow up. Results: To eliminate patient and exam-related factors, such as interactions of the contrast agent with anticoagulants, stenoses in vessels, and changes in heart rate and heart time volume, etc. CH-EUS was performed in 26 patients with a solid lesion in pancreas (16 carcinomas, 9 chronic pancreatitis, and 1 solid pseudopapillary tumor) with certain pathological/cytological results or follow up over 2 years and 5 patients with normal pancreas. Accordingly, for subsequent analyses, only the differences between the lesion and the normal pancreatic tissue of each patient were used. In CH-EUS, the malignant tumor was relatively hypointense compared to the surrounding pancreatic tissue, resulting in consistently positive values in difference of IMAX( IMAX IMAXnormal-IMAXtumor). The TTP was, on average, 36 seconds longer in PDACs than in the normal tissue, while in CP the TTP was similar or only a few seconds longer than in the normal tissue. And the RT in cancerous lesions was significantly longer than in healthy pancreas and non-cancerous lesions. With the use of quantification software, as in our study, this visual impression can thus be detected and measured with a sensitivity that is unachievable with subjective visual impressions alone. Conclusions: Contrast quantification software supplements a subjective visual assessment with objective criteria to facilitate the differential diagnosis of focal lesions in pancreatic cancer and non-cancerous lesions of pancreas, and needs further investigation. Values of the Characteristic Parameters of the Time-Intensity Curve Measured in the Normal Pancreas, and in suspicious lesions of pancreatic cancer, chronic pancreatitis, and SPPT of the pancreas