Abstract

Confocal laser endomicroscopy (CLE) is a promising diagnostic tool for esophageal diseases that can visualize cellular and sub-cellular features that are similar to those used for histomorphologic diagnosis. However, the field size for CLE is typically limited to approximately 0.5mm by 0.5mm, which potentially makes the technique prone to sampling errors. Spectrally encoded confocal microscopy (SECM) is a reflectance confocal microscopy technology, where the wavelength of the light source is used to encode a transverse coordinate of the tissue.

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